Endocrine Abstracts

Background: Matrix metalloproteinase-9 (MMP-9) is an important mediator of invasion and metastasis in neoplasia. The single nucleotide 1562 C/T polymorphism in the promoter region of the MMP-9 genewas shown to increase gene expression and was studied as a susceptibility factor for various cancers.Aim: We aimed to evaluate the impact of the MMP-9 promoter genotype on the risk of developing papillary thyroid cancer (PTC) and to correlate cancer patient gen...

Introduction: Adrenal carcinomas are rare tumor. It has an estimated incidence of ~0.5–2 new cases per million people per year. Just 25% of adults with hormone-secreting adrenal carcinomas present overproduction of both glucocorticoids and androgens. Women develop adrenal carcinomas more often than men.Objectives: We report a case of 47-year-old female presented with weight gain, generalized weakness and hypertension for the last 6 months. Phy...

Multiple endocrine neoplasya type 2 (MEN-2) is a rare hereditary complex disorder caused by a germline activating mutation of the RET proto-oncogene. The estimated prevalence is approximately 1:30.000. Three clinical forms have been described depending on the phenotype: MEN2A (80%), MEN2B and familial medullary thyroid carcinoma (MTC).Clinically, MEN2A present with MTC (80–100%), unilateral or bilateral pheocromocytoma (40%) and primary hyperparath...

Introduction: Cushing syndrome could be missed initially, especially when the presenting features are common in the general population. Before proceeding to the hormonal tests we have to consider that recent studies have shown that up to 50% of patients with CD have different degrees of altered glucose metabolism, up to 80% of CS patients have hypertension independently of their age and sex and hypercorticism changes bone structure and causes vertebral fractures in approximate...

Introduction: Malignant melanoma is a challenging illness for researchers due to unknown hormonal disorders involved in promoting/developing this disease. Some authors accept nowadays, that prolactin is involved in extrapituitary carcinogenesis.The authors aimed to study the status of prolactin in patients with melanocytic lesions and the impact of surgical removal on prolactinemia.Method: The study included 128 adults with melanom...

Background: Low-serum concentrations of 25(OH)-vitamin D are associated with insulin resistance in adults. Recent in vitro studies have suggested that vitamin D may play a role in the regulation of adiponectin, leptin and resistin; since all these adipokines are related to insulin sensitivity modulation, they might represent a link between vitamin D status and insulin resistance.Aim: To identify possible correlations between 25(OH)-vitamin D ser...

Background: Hyponatremia is a common electrolyte abnormality, especially in elderly, hospitalized patients, with a prevalence of severe hyponatremia (<125 mmol/l) up to 6–8%. Pituitary insufficiency (TSH+ACTH) may be difficult to diagnose, but it is important to differentiate it from SIADH and cerebral salt wasting syndrome.Aim: To describe the aetiology and outcome of patients with hyponatremia due to pituitary insufficiency in a tertiary endoc...

Objective: To assess the usefulness of the GnRH analogue Diphereline (Triptoreline) in the evaluation of central gonadal dysfunction in children and adults.Methods: A 18-month retrospective study of dynamic testing of the hypothalamic pituitary gonadal axis in 36 patients, 10 prepubescent children (<13 years for girls and 14 years for boys) and 26 postpubescent subjects. The children were investigated for disorders of sexual development while the adu...

Introduction: Ovarian hyperthecosis is a rare cause of severe hyperandrogenism. Unlike PCOS, it is also described in postmenopausal women.We report the case of a 67-year-old obese (BMI=37.5 kg/m2) and dyslipidemic woman, gravid 5 para 3, menopause at 49, with poor controlled type 2 diabetes mellitus (HbA1c=10%). She was in treatment with insulin for the last 12 years, currently on 168 U/24 h (1.71 U/kg)- indicating severe insulin resistance, c...

Background: Endocrine hypertension accounts for around 3% of the secondary forms of hypertension and screening of young hypertensive patients for secondary causes is mandatory.Aim: To present difficulties in endocrine assessment of arterial hypertension in people younger than 40 years.Patients and methods: Twenty-two patients (15 M/7 F), aged 27.1±7.7 years (range:16-40 years), with systemic hypertension (systolic blood pressu...